Silk and the City of Seduction

From the letters page: Silk and the City of Seduction is a sandbox game from Devious Delight Games, built in Ren'Py. It centres on corruption, futa/trans and mind control, with a female protagonist. The game is ongoing at version 3.31 Public and available for Windows, Mac and Linux. Download size is about 2.4 GB.

From the box: “Follow Silk, a woman who developed powers once bitten by a radioactive spider, as she embarks on a quest to save the city she calls home.”